BDBM275396 1-{(3S,4S)-4-[(5- fluoropyridin-3- yl)oxy]pyrrolidin-3-yl}-3-[1- (2-methylpyridin-4-yl)-1H- pyrazolo[3,4-c]pyridin-5- yl]urea::US9884048, Example 275

SMILES Cc1cc(ccn1)-n1ncc2cc(NC(=O)N[C@H]3CNC[C@@H]3Oc3cncc(F)c3)ncc12

InChI Key InChIKey=FHBGZJYULOQIAJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 275396   

TargetMitogen-activated protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM275396(1-{(3S,4S)-4-[(5- fluoropyridin-3- yl)oxy]pyrrolid...)
Affinity DataIC50: 327nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent