BDBM276830 US10072001, Example 16::US10259811, Example 16

SMILES O=C(CC#N)N1CC[C@H](C1)Oc1ccc(cc1C#N)-c1ccnc2[nH]c(cc12)-c1ccc(cc1)N1CCOCC1

InChI Key InChIKey=WMAOLQILCBAPMK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 276830   

TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM276830(US10072001, Example 16 | US10259811, Example 16)
Affinity DataIC50: 4.32nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Gilead Sciences

US Patent
LigandPNGBDBM276830(US10072001, Example 16 | US10259811, Example 16)
Affinity DataIC50: 4.32nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent

LigandPNGBDBM276830(US10072001, Example 16 | US10259811, Example 16)
Affinity DataIC50: 13.8nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
Go to US Patent

LigandPNGBDBM276830(US10072001, Example 16 | US10259811, Example 16)
Affinity DataIC50: 13.8nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
Go to US Patent