BDBM277394 2,2-difluoro-1-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)ethan-1-one::US10072026, Example 5::US10072026, Example 5-36::US10947254, Example 5::US11780852, Example 5

SMILES Cc1cc(Nc2cc3ncccc3c(N[C@H]3C[C@@H]4CC[C@H](C3)N4C(=O)C(F)F)n2)n[nH]1

InChI Key InChIKey=NXQPVBKWWDJCIC-UHFFFAOYSA-N

Data  16 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 277394   

TargetTyrosine-protein kinase JAK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi: <0.100nMpH: 7.5Assay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi:  0.550nMpH: 7.5Assay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi:  0.550nMpH: 7.5Assay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetTyrosine-protein kinase JAK3(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi:  0.550nMpH: 7.5Assay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi:  0.550nMpH: 7.5Assay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/21/2018
Entry Details
Copy BDB DOIUS Patent

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TargetTyrosine-protein kinase JAK1(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi:  0.550nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/28/2021
Entry Details
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TargetTyrosine-protein kinase JAK1(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi:  0.550nMAssay Description:Biochemical JAK and Off-Target Kinase Assays. A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kin...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/17/2023
Entry Details
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TargetTyrosine-protein kinase JAK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi:  50nMpH: 7.5Assay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/21/2018
Entry Details
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TargetTyrosine-protein kinase JAK3(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi:  50nMpH: 7.5Assay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/21/2018
Entry Details
Copy BDB DOIUS Patent

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TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi:  50nMpH: 7.5Assay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/21/2018
Entry Details
Copy BDB DOIUS Patent

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TargetTyrosine-protein kinase JAK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi:  50nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/28/2021
Entry Details
Copy BDB DOIUS Patent

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TargetTyrosine-protein kinase JAK3(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi:  50nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/28/2021
Entry Details
Copy BDB DOIUS Patent

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TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi:  50nMAssay Description:A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kinase reaction buffer (50 mM HEPES, pH 7.5, 0.01%...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/28/2021
Entry Details
Copy BDB DOIUS Patent

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TargetTyrosine-protein kinase JAK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi:  50.5nMAssay Description:Biochemical JAK and Off-Target Kinase Assays. A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kin...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/17/2023
Entry Details
Copy BDB DOIUS Patent

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TargetTyrosine-protein kinase JAK3(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi:  50.5nMAssay Description:Biochemical JAK and Off-Target Kinase Assays. A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kin...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/17/2023
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Theravance Biopharma R&D Ip

US Patent

LigandBDBM277394(US10072026, Example 5 | 2,2-difluoro-1-((1R,3s,5S)...)Copy SMILESCopy InChI

Affinity DataKi:  50.5nMAssay Description:Biochemical JAK and Off-Target Kinase Assays. A panel of four LanthaScreen JAK biochemical assays (JAK1, 2, 3 and Tyk2) were carried in a common kin...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/17/2023
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL