BDBM278519 (S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tetrahydrofuran-2-yl)methylamino)-1'H-spiro[cyclopropane-1,4'-[2,7]naphthyridin]-3'(2'H)-one::US10040790, Example 35::US10450313, Example 35::US10947230, Example 35::US11530214, Example 35

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(NC[C@@H]4CCCO4)cc3C3(CC3)C2=O)c1F

InChI Key InChIKey=WLDSTFTUIFOSDT-AWEZNQCLSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 278519   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278519((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tet...)
Affinity DataIC50: <100nMpH: 7.5Assay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278519((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tet...)
Affinity DataIC50: <100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278519((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tet...)
Affinity DataIC50: <100nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278519((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tet...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278519((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tet...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278519((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tet...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278519((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tet...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278519((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tet...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278519((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tet...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278519((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tet...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278519((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tet...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte Holdings

US Patent
LigandPNGBDBM278519((S)-2'-(2,6-difluoro-3,5-dimethoxyphenyl)-6'-((tet...)
Affinity DataIC50: <100nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent