BDBM279062 1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)methyl]-5-(2-propoxy-3-pyridyl)pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 93::US10512632, Example 93::US10766893, Example S93::US10806718, Example 93::US11026923, Example 93::US11491140, Example 93::US11634416, Example 93

SMILES CCCOc1ncccc1-c1cc(NCc2nnn(C)n2)c2n(nc(C)c2n1)C(C)C

InChI Key InChIKey=IEZRRRCALKIRBN-UHFFFAOYSA-N

Data  21 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 279062   

LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 0.960nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
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LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 0.960nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 0.960nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
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LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 0.960nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
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LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 0.960nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
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LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 0.960nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 0.960nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
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LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 4.30nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 4.30nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 4.30nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
Go to US Patent

LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 4.30nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent

LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 4.30nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 4.30nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 4.30nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
Go to US Patent

LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
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LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 17nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
Go to US Patent

LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/20/2023
Entry Details
Go to US Patent

LigandPNGBDBM279062(1-isopropyl-3-methyl-N-[(2-methyltetrazol-5-yl)met...)
Affinity DataIC50: 17nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2020
Entry Details
Go to US Patent