BDBM279684 US10035797, Compound 22::US10428068, Compound 22::US10844056, Compound 22::US9630965, Compound 22

SMILES Nc1nccc2n(CCC#C)c(Sc3cc4OCOc4cc3Br)nc12

InChI Key InChIKey=WJUCIPQCFQYPPB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 279684   

TargetHeat shock protein HSP 90-alpha(Human)
Curis

US Patent
LigandPNGBDBM279684(US10035797, Compound 22 | US9630965, Compound 22 |...)
Affinity DataIC50: 5.50E+3nMpH: 7.3Assay Description:A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Curis

US Patent
LigandPNGBDBM279684(US10035797, Compound 22 | US9630965, Compound 22 |...)
Affinity DataIC50: 5.50E+3nMAssay Description:A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2019
Entry Details
US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Curis

US Patent
LigandPNGBDBM279684(US10035797, Compound 22 | US9630965, Compound 22 |...)
Affinity DataIC50: 5.50E+3nMAssay Description:HSP90: A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent

TargetHeat shock protein HSP 90-alpha(Human)
Curis

US Patent
LigandPNGBDBM279684(US10035797, Compound 22 | US9630965, Compound 22 |...)
Affinity DataIC50: 5.50E+3nMAssay Description:A fluorescein isothiocyanate (FITC) labeled GM was purchase from InvivoGen (ant-fgl-1). The interaction between HSP90 and labeled GM forms the basis ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent