BDBM280747 3-(4-{4-Amino-5-methyl-6-oxo-2-(1-(3,3,4,4,4-pentafluorobutyl)-2,3-dihydro-1H-pyrazolo[3,4-b]pyridin-3-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-5-yl}phenyl)-2,2-dimethylpropanoic acid::US10030027, Example 9B::US10428076, Example 9B

SMILES CC(C)(Cc1ccc(cc1)C1(C)C(=O)Nc2nc(nc(N)c12)-c1nn(CCC(F)(F)C(F)(F)F)c2ncccc12)C(O)=O

InChI Key InChIKey=WMACXEBVRSRQCO-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 280747   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM280747(3-(4-{4-Amino-5-methyl-6-oxo-2-(1-(3,3,4,4,4-penta...)
Affinity DataKi:  0.374nMpH: 7.4Assay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2018
Entry Details
US Patent

TargetGuanylate cyclase soluble subunit alpha-1/beta-1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM280747(3-(4-{4-Amino-5-methyl-6-oxo-2-(1-(3,3,4,4,4-penta...)
Affinity DataKi:  0.374nMAssay Description:The binding buffer was composed of 50 mM triethanolamine, pH 7.4, 3 mM MgCl2, 0.025% BSA, 2 mM dithiothreitol (DTT), 300 μM DETA/NO and 400 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent