BDBM283074 N-((6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- imidazol-5-yl)imidazo[1,2-a]pyridin-3-yl)methyl)-2,2- difluoroethanamine::US10287295, Example 275'::US11352360, Example 275'::US9884868, Example 275'

SMILES FC(F)CNCc1cnc2ccc(cn12)-c1c(ncn1CC(F)F)-c1ccc(F)cc1

InChI Key InChIKey=MVKBXVJVQFMZHM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 283074   

TargetTGF-beta receptor type-1 [T204D](Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM283074(N-((6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H...)
Affinity DataIC50: 121nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Syngene International

US Patent
LigandPNGBDBM283074(N-((6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H...)
Affinity DataIC50: 121nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent

TargetTGF-beta receptor type-1(Human)
Syngene International

US Patent
LigandPNGBDBM283074(N-((6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H...)
Affinity DataIC50: 121nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
US Patent

TargetTGF-beta receptor type-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM283074(N-((6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H...)
Affinity DataIC50: 1.50E+4nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetTGF-beta receptor type-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM283074(N-((6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H...)
Affinity DataIC50: 1.50E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent

TargetTGF-beta receptor type-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM283074(N-((6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H...)
Affinity DataIC50: 1.50E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
US Patent