BDBM283304 5-{3-Fluoro-2'-[(4-pyrimidin-2-ylpiperazin-1- yl)sulfonyl]biphenyl-4-yl}pyrazin-2-amine::US9745328, Compound 177::US9884878, Compound 177

SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CCN(CC1)c1ncccn1

InChI Key InChIKey=YDAYNMYVMXKTEZ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 283304   

TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM283304(5-{3-Fluoro-2'-[(4-pyrimidin-2-ylpiperazin-1- yl)s...)
Affinity DataKi: <0.100nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFlap endonuclease 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM283304(5-{3-Fluoro-2'-[(4-pyrimidin-2-ylpiperazin-1- yl)s...)
Affinity DataKi: <1nMAssay Description:The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent