BDBM284004 US10023570, Example 22::US10174027, Example 22

SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)CNC(C)(C)C)c2c(cnn2c1)C#N

InChI Key InChIKey=CKCHGEMNZMYHFZ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 284004   

LigandPNGBDBM284004(US10023570, Example 22 | US10174027, Example 22)
Affinity DataIC50: 14.8nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
US Patent

LigandPNGBDBM284004(US10023570, Example 22 | US10174027, Example 22)
Affinity DataIC50: 163nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284004(US10023570, Example 22 | US10174027, Example 22)
Affinity DataIC50: 14.8nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandPNGBDBM284004(US10023570, Example 22 | US10174027, Example 22)
Affinity DataIC50: 163nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284004(US10023570, Example 22 | US10174027, Example 22)
Affinity DataIC50: 14.8nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandPNGBDBM284004(US10023570, Example 22 | US10174027, Example 22)
Affinity DataIC50: 163nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent