BDBM284105 4-(6-(4-(4,4-difluoropiperidine- 1-carbonyl)piperazin-1- yl)pyridin-3-yl)-6-(1-methyl- 1H-pyrazol-4-yl)pyrazolo[1,5- a]pyridine-3-carbonitrile::US10023570, Example 115::US10174027, Example 115

SMILES Cn1cc(cn1)-c1cc(-c2ccc(nc2)N2CCN(CC2)C(=O)N2CCC(F)(F)CC2)c2c(cnn2c1)C#N

InChI Key InChIKey=BDXKLTDCPYOAAX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 284105   

LigandPNGBDBM284105(US10023570, Example 115 | 4-(6-(4-(4,4-difluoropip...)
Affinity DataIC50: 32.1nMpH: 7.4Assay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284105(US10023570, Example 115 | 4-(6-(4-(4,4-difluoropip...)
Affinity DataIC50: 32.1nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM284105(US10023570, Example 115 | 4-(6-(4-(4,4-difluoropip...)
Affinity DataIC50: 32.1nMAssay Description:Compounds of General Formula I were screened for their ability to inhibit wild type and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent