BDBM285332 4-(2,4-difluorophenoxy)-5-(1-methyl-6- oxopyridin-3-yl)-1- (methylsulfonylmethyl)pyridin-2-one::US10023592, Example 386

SMILES Cn1cc(ccc1=O)-c1cn(CS(C)(=O)=O)c(=O)cc1Oc1ccc(F)cc1F

InChI Key InChIKey=HLEXBJIIMFAIFH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 285332   

TargetBromodomain-containing protein 4(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 285332BDBM285332(US10023592, Example 386 | 4-(2,4-difluorophenoxy)-...)
Affinity DataIC50: 500nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
US Patent