BDBM285436 N-[2-ethyl-8-(2-methyl-1-oxoisoquinolin-4-yl)- 3,4-dihydro-2H-chromen-6-yl] methanesulfonamide::US10023592, Example 490

SMILES CCC1CCc2cc(NS(C)(=O)=O)cc(c2O1)-c1cn(C)c(=O)c2ccccc12

InChI Key InChIKey=UBIHPKBMMBTFTR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 285436   

TargetBromodomain-containing protein 4(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM285436(US10023592, Example 490 | N-[2-ethyl-8-(2-methyl-1...)
Affinity DataIC50: 500nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
US Patent