BDBM287722 US10085984, Example 100::US11040034, Ex. No. 100

SMILES Cc1cc(-c2nc3cc(F)c(F)cc3n2C2CC2)c(C)nn1

InChI Key InChIKey=INZKDTARRIIUFL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 287722   

TargetCytochrome P450 11B2, mitochondrial(Human)
Viamet Pharmaceuticals (Bermuda)

US Patent
LigandPNGBDBM287722(US10085984, Example 100 | US11040034, Ex. No. 100)
Affinity DataIC50: 1.00E+3nMAssay Description:V79-4 cells expressing recombinant andrenodoxin and andrenodoxin reductase with either recombinant human CYP11B2 or CYP11B1 were prepared according t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Viamet Pharmaceuticals (Bermuda)

US Patent
LigandPNGBDBM287722(US10085984, Example 100 | US11040034, Ex. No. 100)
Affinity DataIC50: 1.00E+3nMAssay Description:V79-4 cells expressing recombinant andrenodoxin and andrenodoxin reductase with either recombinant human CYP11B2 or CYP11B1 were prepared according t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2019
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Viamet Pharmaceuticals (Bermuda)

US Patent
LigandPNGBDBM287722(US10085984, Example 100 | US11040034, Ex. No. 100)
Affinity DataIC50: 1.00E+4nMAssay Description:Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Viamet Pharmaceuticals (Bermuda)

US Patent
LigandPNGBDBM287722(US10085984, Example 100 | US11040034, Ex. No. 100)
Affinity DataIC50: 1.00E+4nMAssay Description:Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
US Patent