BDBM288956 US10092563, Compound 93

SMILES Nc1nc(N)c(C#N)c(N[C@@H](C2CC2)c2nc3cccc(Cl)c3c(=O)n2N2CCN(Cc3ccccc3)CC2)n1

InChI Key InChIKey=JWEPSBSKZRSPSL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 288956   

LigandPNGBDBM288956(US10092563, Compound 93)
Affinity DataIC50: 1.80E+4nMpH: 7.4Assay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Gilead Sciences

US Patent
LigandPNGBDBM288956(US10092563, Compound 93)
Affinity DataIC50: 4.80E+4nMpH: 7.4Assay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent

LigandPNGBDBM288956(US10092563, Compound 93)
Affinity DataIC50: 1.30E+6nMpH: 7.4Assay Description:TR-FRET monitored the formation of 3,4,5-inositol triphosphate molecule that competed with fluorescently labeled PIPS for binding to the GRP-1 plecks...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/18/2019
Entry Details
US Patent