BDBM289891 2-Hydroxy-N-methyl-N-(1-{6-[5-(2H- pyrazol-3-yl)-pyrimidin-2-yloxy]- naphthalen-2-ylmethyl}-piperidin- 4-yl)-acetamide::US9573957, Example 31

SMILES CN(C1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)CC1)C(=O)CO

InChI Key InChIKey=DNWOWSSPSHFOEA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 289891   

TargetLeukotriene A-4 hydrolase(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 289891BDBM289891(2-Hydroxy-N-methyl-N-(1-{6-[5-(2H- pyrazol-3-yl)-p...)
Affinity DataIC50: 1.5nMpH: 7.5 T: 2°CAssay Description:The compounds of the invention are assessed for the ability to interact with human LTA4 hydrolase in an enzymatic assay that measures the ability of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent