BDBM291487 US10413562, Compound A206::US9580449, Example A206::methyl 3-((4-(4-(3-acrylamidophenoxy)-6-aminopyrimidin-5-yl)-1H-pyrazol-1-yl)methyl)benzoate

SMILES COC(=O)c1cccc(Cn2cc(cn2)-c2c(N)ncnc2Oc2cccc(NC(=O)C=C)c2)c1

InChI Key InChIKey=MHUZGHFCECNFOF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 291487   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM291487(US10413562, Compound A206 | US9580449, Example A20...)
Affinity DataIC50: <100nMAssay Description:2.5× stocks of full-length human BTK (08-080) from CarnaBio USA, Inc., Natick, Mass., 1.6×ATP and appropriate kinKDR peptide substrate (FITC-AHA-EEPL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM291487(US10413562, Compound A206 | US9580449, Example A20...)
Affinity DataIC50: <100nMpH: 7.5 T: 2°CAssay Description:The following describes a microfluidic, off-chip mobility shift kinase assay used to measure inherent potency of compounds against BTK enzyme. Compou...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent