BDBM291764 5-(5-(((2,3-dihydrobenzofuran-4-yl)methyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)-N-methylpicolinamide::US11207325, Example 79::US9580437, Example 79

SMILES CNC(=O)c1ccc(cn1)-c1cnc(NCc2cccc3OCCc23)n2cnnc12

InChI Key InChIKey=CDLYHLQXPRDLDO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 291764   

LigandChemical structure of BindingDB Monomer ID 291764BDBM291764(US9580437, Example 79 | 5-(5-(((2,3-dihydrobenzofu...)
Affinity DataIC50: 57.5nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291764BDBM291764(US9580437, Example 79 | 5-(5-(((2,3-dihydrobenzofu...)
Affinity DataIC50: 57.5nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291764BDBM291764(US9580437, Example 79 | 5-(5-(((2,3-dihydrobenzofu...)
Affinity DataIC50: 103nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291764BDBM291764(US9580437, Example 79 | 5-(5-(((2,3-dihydrobenzofu...)
Affinity DataIC50: 103nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent