BDBM291818 4-((5-(5-(((2,3-dihydrobenzofuran-4-yl)methyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)pyridin-2-yl)methyl)piperazin-2-one::US11207325, Example 133::US9580437, Example 133

SMILES O=C1CN(Cc2ccc(cn2)-c2cnc(NCc3cccc4OCCc34)n3cnnc23)CCN1

InChI Key InChIKey=DMNYVPRPVYTJBJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291818   

LigandChemical structure of BindingDB Monomer ID 291818BDBM291818(US9580437, Example 133 | 4-((5-(5-(((2,3-dihydrobe...)
Affinity DataIC50: 8.70nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291818BDBM291818(US9580437, Example 133 | 4-((5-(5-(((2,3-dihydrobe...)
Affinity DataIC50: 8.70nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291818BDBM291818(US9580437, Example 133 | 4-((5-(5-(((2,3-dihydrobe...)
Affinity DataIC50: 22.3nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291818BDBM291818(US9580437, Example 133 | 4-((5-(5-(((2,3-dihydrobe...)
Affinity DataIC50: 22.3nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291818BDBM291818(US9580437, Example 133 | 4-((5-(5-(((2,3-dihydrobe...)
Affinity DataIC50: 142nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291818BDBM291818(US9580437, Example 133 | 4-((5-(5-(((2,3-dihydrobe...)
Affinity DataIC50: 142nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent