BDBM291821 N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(4-(trifluoromethyl)pyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine::US11207325, Example 166::US9580437, Example 136::US9580437, Example 166

SMILES Fc1ccc2OCCc2c1CNc1ncc(-c2cnccc2C(F)(F)F)c2nncn12

InChI Key InChIKey=YNALWGRJSRAASC-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 291821   

LigandChemical structure of BindingDB Monomer ID 291821BDBM291821(US9580437, Example 166 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 11.1nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291821BDBM291821(US9580437, Example 166 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 11.1nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291821BDBM291821(US9580437, Example 166 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 15.9nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291821BDBM291821(US9580437, Example 166 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 15.9nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291821BDBM291821(US9580437, Example 166 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 26.6nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291821BDBM291821(US9580437, Example 166 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 26.6nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291821BDBM291821(US9580437, Example 166 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 31nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291821BDBM291821(US9580437, Example 166 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 31nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291821BDBM291821(US9580437, Example 166 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 41.8nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291821BDBM291821(US9580437, Example 166 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 41.8nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291821BDBM291821(US9580437, Example 166 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 80.4nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291821BDBM291821(US9580437, Example 166 | N-((5-fluoro-2,3-dihydrob...)
Affinity DataIC50: 80.4nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent