BDBM291834 8-(1-cyclopropyl-1H-pyrazol-4-yl)-N-((2,3-dihydrobenzofuran-4-yl)methyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine::US11207325, Example 149::US9580437, Example 149

SMILES C(Nc1ncc(-c2cnn(c2)C2CC2)c2nncn12)c1cccc2OCCc12

InChI Key InChIKey=MGRDRQOHZLHNJD-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291834   

LigandChemical structure of BindingDB Monomer ID 291834BDBM291834(US9580437, Example 149 | 8-(1-cyclopropyl-1H-pyraz...)
Affinity DataIC50: 16.9nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291834BDBM291834(US9580437, Example 149 | 8-(1-cyclopropyl-1H-pyraz...)
Affinity DataIC50: 16.9nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291834BDBM291834(US9580437, Example 149 | 8-(1-cyclopropyl-1H-pyraz...)
Affinity DataIC50: 33.7nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291834BDBM291834(US9580437, Example 149 | 8-(1-cyclopropyl-1H-pyraz...)
Affinity DataIC50: 33.7nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291834BDBM291834(US9580437, Example 149 | 8-(1-cyclopropyl-1H-pyraz...)
Affinity DataIC50: 220nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291834BDBM291834(US9580437, Example 149 | 8-(1-cyclopropyl-1H-pyraz...)
Affinity DataIC50: 220nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent