BDBM291884 5-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)-N,N,6-trimethylpicolinamide::US11207325, Example 199::US9580437, Example 199

SMILES CN(C)C(=O)c1ccc(c(C)n1)-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12

InChI Key InChIKey=DMOUAYZQHPZOBL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291884   

LigandPNGBDBM291884(US9580437, Example 199 | 5-(5-(((5-fluoro-2,3-dihy...)
Affinity DataIC50: 4.20nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

LigandPNGBDBM291884(US9580437, Example 199 | 5-(5-(((5-fluoro-2,3-dihy...)
Affinity DataIC50: 7.20nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

LigandPNGBDBM291884(US9580437, Example 199 | 5-(5-(((5-fluoro-2,3-dihy...)
Affinity DataIC50: 5nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandPNGBDBM291884(US9580437, Example 199 | 5-(5-(((5-fluoro-2,3-dihy...)
Affinity DataIC50: 4.20nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandPNGBDBM291884(US9580437, Example 199 | 5-(5-(((5-fluoro-2,3-dihy...)
Affinity DataIC50: 7.20nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandPNGBDBM291884(US9580437, Example 199 | 5-(5-(((5-fluoro-2,3-dihy...)
Affinity DataIC50: 5nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent