BDBM291895 N-(benzofuran-4-ylmethyl)-8-(4-(1-(pyrrolidin-1-yl)ethyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine::US11207325, Example 210::US9580437, Example 210

SMILES CC(N1CCCC1)c1ccc(cc1)-c1cnc(NCc2cccc3occc23)n2cnnc12

InChI Key InChIKey=ZBNBGTVUPQTUCA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 291895   

LigandChemical structure of BindingDB Monomer ID 291895BDBM291895(US9580437, Example 210 | N-(benzofuran-4-ylmethyl)...)
Affinity DataIC50: 18.5nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291895BDBM291895(US9580437, Example 210 | N-(benzofuran-4-ylmethyl)...)
Affinity DataIC50: 18.5nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291895BDBM291895(US9580437, Example 210 | N-(benzofuran-4-ylmethyl)...)
Affinity DataIC50: 21.4nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291895BDBM291895(US9580437, Example 210 | N-(benzofuran-4-ylmethyl)...)
Affinity DataIC50: 21.4nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent