BDBM291901 (4-(5-((benzofuran-4-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)phenyl)(pyrrolidin-1-yl)methanone::US11207325, Example 216::US9580437, Example 216

SMILES O=C(N1CCCC1)c1ccc(cc1)-c1cnc(NCc2cccc3occc23)n2cnnc12

InChI Key InChIKey=TZZZJLSKOPRNFT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 291901   

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291901BDBM291901(US9580437, Example 216 | (4-(5-((benzofuran-4-ylme...)
Affinity DataIC50: 132nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291901BDBM291901(US9580437, Example 216 | (4-(5-((benzofuran-4-ylme...)
Affinity DataIC50: 132nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291901BDBM291901(US9580437, Example 216 | (4-(5-((benzofuran-4-ylme...)
Affinity DataIC50: 183nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291901BDBM291901(US9580437, Example 216 | (4-(5-((benzofuran-4-ylme...)
Affinity DataIC50: 183nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent