BDBM291903 N-(benzofuran-4-ylmethyl)-8-(pyridin-4-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine::US11207325, Example 218::US9580437, Example 218

SMILES C(Nc1ncc(-c2ccncc2)c2nncn12)c1cccc2occc12

InChI Key InChIKey=ITXKZEROEOVKAH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 291903   

LigandChemical structure of BindingDB Monomer ID 291903BDBM291903(US9580437, Example 218 | N-(benzofuran-4-ylmethyl)...)
Affinity DataIC50: 26.3nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291903BDBM291903(US9580437, Example 218 | N-(benzofuran-4-ylmethyl)...)
Affinity DataIC50: 26.3nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291903BDBM291903(US9580437, Example 218 | N-(benzofuran-4-ylmethyl)...)
Affinity DataIC50: 38.6nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291903BDBM291903(US9580437, Example 218 | N-(benzofuran-4-ylmethyl)...)
Affinity DataIC50: 38.6nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent