BDBM291929 3-(5-(((5-fluoro-3-hydroxy-2,3-dihydrobenzofuran-4-yl)methyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)-2-methylpyridine 1-oxide::BDBM531321::US9580437, Example 244

SMILES Cc1c(ccc[n+]1[O-])-c1cnc(NCc2c3C(O)COc3ccc2F)n2cnnc12

InChI Key InChIKey=MDPWQZIGNRNWIA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 291929   

LigandChemical structure of BindingDB Monomer ID 291929BDBM291929(US9580437, Example 244 | 3-(5-(((5-fluoro-3-hydrox...)
Affinity DataIC50: 11.7nMpH: 8.0Assay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291929BDBM291929(US9580437, Example 244 | 3-(5-(((5-fluoro-3-hydrox...)
Affinity DataIC50: 11.7nMAssay Description:To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291929BDBM291929(US9580437, Example 244 | 3-(5-(((5-fluoro-3-hydrox...)
Affinity DataIC50: 38.9nMpH: 8.0Assay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291929BDBM291929(US9580437, Example 244 | 3-(5-(((5-fluoro-3-hydrox...)
Affinity DataIC50: 38.9nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 291929BDBM291929(US9580437, Example 244 | 3-(5-(((5-fluoro-3-hydrox...)
Affinity DataIC50: 242nMAssay Description:Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent

TargetPolycomb protein EED(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 291929BDBM291929(US9580437, Example 244 | 3-(5-(((5-fluoro-3-hydrox...)
Affinity DataIC50: 242nMAssay Description:Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent