BDBM292613 2-((R)-2-carbamoylpyrrolidin-1-yl)-N-((S)-2-(diethylamino)propyl)-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide::US10100058, Example 269

SMILES CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CCC[C@@H]1C(N)=O

InChI Key InChIKey=QPQPXDMMCSUNLM-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292613   

LigandPNGBDBM292613(US10100058, Example 269 | 2-((R)-2-carbamoylpyrrol...)
Affinity DataIC50: 6.05nMAssay Description:The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve...More data for this Ligand-Target Pair
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Date in BDB:
2/21/2019
Entry Details
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LigandPNGBDBM292613(US10100058, Example 269 | 2-((R)-2-carbamoylpyrrol...)
Affinity DataEC50:  166nMAssay Description:CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
Go to US Patent