BDBM293648 US10106527, Compound 454::US10544128, Compound 454::US11548872, Compound 454::US20230286945, Compound 454::US9951048, Compound 454

SMILES CN1CCN(CC1)c1nccc(C(=O)Nc2cc3cc(ccc3cn2)-c2cnn(C)c2)c1F

InChI Key InChIKey=ZEJUSAPVUHKEDK-UHFFFAOYSA-N

Data  10 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 293648   

LigandPNGBDBM293648(US10106527, Compound 454 | US9951048, Compound 454...)
Affinity DataEC50:  5.90nMAssay Description:The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Divis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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LigandPNGBDBM293648(US10106527, Compound 454 | US9951048, Compound 454...)
Affinity DataEC50:  5.90nMAssay Description:The DYRK1A kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Divis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent

LigandPNGBDBM293648(US10106527, Compound 454 | US9951048, Compound 454...)
Affinity DataEC50:  5.90nMAssay Description:The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent

LigandPNGBDBM293648(US10106527, Compound 454 | US9951048, Compound 454...)
Affinity DataEC50:  5.90nMAssay Description:The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Divis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
Go to US Patent

LigandPNGBDBM293648(US10106527, Compound 454 | US9951048, Compound 454...)
Affinity DataEC50:  5.90nMT: 2°CAssay Description:Briefly, recombinant DYRK1A kinase, ATP and Ser/Thr peptide 18 were prepared in 1× Kinase buffer to final concentrations of 0.19 μg/mL, 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
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TargetProto-oncogene Wnt-1(Human)
Samumed

US Patent
LigandPNGBDBM293648(US10106527, Compound 454 | US9951048, Compound 454...)
Affinity DataEC50:  324nMAssay Description:The screening assay for Wnt activity is described as follows. Reporter cell lines can be generated by stably transducing cancer cell lines (e.g., col...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
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TargetGlycogen synthase kinase-3 beta(Human)
Samumed

US Patent
LigandPNGBDBM293648(US10106527, Compound 454 | US9951048, Compound 454...)
Affinity DataEC50:  1.35E+3nMT: 2°CAssay Description:Briefly, recombinant GSK3β kinase, ATP and Ser/Thr peptide 09 are prepared in 1× Kinase buffer to final concentrations of 0.04 μg/mL, 46 &#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details
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TargetGlycogen synthase kinase-3 beta(Human)
Samumed

US Patent
LigandPNGBDBM293648(US10106527, Compound 454 | US9951048, Compound 454...)
Affinity DataEC50:  1.35E+3nMAssay Description:The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2020
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Samumed

US Patent
LigandPNGBDBM293648(US10106527, Compound 454 | US9951048, Compound 454...)
Affinity DataEC50:  1.35E+3nMAssay Description:The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent

TargetGlycogen synthase kinase-3 beta(Human)
Samumed

US Patent
LigandPNGBDBM293648(US10106527, Compound 454 | US9951048, Compound 454...)
Affinity DataEC50:  1.35E+3nMAssay Description:The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies a Di...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent