BDBM296486 6-(2-methoxyethoxy)-4- (6-(4-((2- methylpyridin-4- yl)methyl)piperazin-1- yl)pyridin-3- yl)pyrazolo[1,5- a]pyridine-3- carbonitrile::US10112942, Example 220::US10137124, Example 220::US10172851, Example 220::US10555944, Example 220::US10953005, Example 220

SMILES COCCOc1cc(-c2ccc(nc2)N2CCN(Cc3ccnc(C)c3)CC2)c2c(cnn2c1)C#N

InChI Key InChIKey=UTXDXFNTDUFNSB-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 296486   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296486(US10112942, Example 220 | 6-(2-methoxyethoxy)-4- (...)
Affinity DataIC50: 102nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

LigandPNGBDBM296486(US10112942, Example 220 | 6-(2-methoxyethoxy)-4- (...)
Affinity DataIC50: 102nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

LigandPNGBDBM296486(US10112942, Example 220 | 6-(2-methoxyethoxy)-4- (...)
Affinity DataIC50: 102nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296486(US10112942, Example 220 | 6-(2-methoxyethoxy)-4- (...)
Affinity DataIC50: 102nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM296486(US10112942, Example 220 | 6-(2-methoxyethoxy)-4- (...)
Affinity DataIC50: 102nMpH: 7.4Assay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent

LigandPNGBDBM296486(US10112942, Example 220 | 6-(2-methoxyethoxy)-4- (...)
Affinity DataIC50: 661nMAssay Description:RET: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

LigandPNGBDBM296486(US10112942, Example 220 | 6-(2-methoxyethoxy)-4- (...)
Affinity DataIC50: 661nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
Go to US Patent

LigandPNGBDBM296486(US10112942, Example 220 | 6-(2-methoxyethoxy)-4- (...)
Affinity DataIC50: 661nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

LigandPNGBDBM296486(US10112942, Example 220 | 6-(2-methoxyethoxy)-4- (...)
Affinity DataIC50: 661nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2019
Entry Details
Go to US Patent

LigandPNGBDBM296486(US10112942, Example 220 | 6-(2-methoxyethoxy)-4- (...)
Affinity DataIC50: 661nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
Go to US Patent