BDBM299471 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-((S)-1-(N-(2,2,2-trifluoroethyl)methylsulfonamido)butan-2-yl)piperidin-3-yl)acetic acid::US9593129, Example 147

SMILES CC[C@@H](CN(CC(F)(F)F)S(C)(=O)=O)N1[C@@H]([C@H](C[C@](C)(CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1

InChI Key InChIKey=ZPUIHUUGFFPQNO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299471   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 299471BDBM299471(US9593129, Example 147 | 2-((3R,5R,6S)-5-(3-chloro...)
Affinity DataIC50: 2nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2019
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 299471BDBM299471(US9593129, Example 147 | 2-((3R,5R,6S)-5-(3-chloro...)
Affinity DataIC50: 10nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/12/2019
Entry Details
US Patent