BDBM300460 6-(2-fluorophenyl)-N-{3-[(morpholin-4-ylacetyl)amino]-4-(trifluoromethoxy)phenyl}nicotinamide::US10130633, Example 30

SMILES Fc1ccccc1-c1ccc(cn1)C(=O)Nc1ccc(OC(F)(F)F)c(NC(=O)CN2CCOCC2)c1

InChI Key InChIKey=LMEAJULYWCIHIQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 300460   

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300460(6-(2-fluorophenyl)-N-{3-[(morpholin-4-ylacetyl)ami...)
Affinity DataIC50: 90.1nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300460(6-(2-fluorophenyl)-N-{3-[(morpholin-4-ylacetyl)ami...)
Affinity DataIC50: 1.40E+3nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before beginning the test at 10000 cells per well in a 384 micro titre plate (MT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300460(6-(2-fluorophenyl)-N-{3-[(morpholin-4-ylacetyl)ami...)
Affinity DataIC50: 5.00E+4nMAssay Description:In preparation of the assay, the two cell lines were plated 24 hours before at 10000 cells per well of a 384 micro titre plate (MTP) in 30 μL gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent

TargetProtein Wnt-3a(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM300460(6-(2-fluorophenyl)-N-{3-[(morpholin-4-ylacetyl)ami...)
Affinity DataIC50: 5.00E+4nMAssay Description:HEK293 cells were cotransfected with the FOP control vector and pcDNA3. The FOP vector is identical to the TOP construct, but it contains instead of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
US Patent