BDBM304593 US10144715, Compound 46-59::methyl 2-(methylsulfonyl)-4-(3-phenyl-4-((6-(trifluoromethyl)pyridin-3-yl)methyl)piperazin-1-yl)benzoate

SMILES COC(=O)c1ccc(cc1S(C)(=O)=O)N1CCN(Cc2ccc(nc2)C(F)(F)F)C(C1)c1ccccc1

InChI Key InChIKey=OZCHBKWUMMUQCS-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 304593   

TargetOxysterols receptor LXR-beta(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM304593(methyl 2-(methylsulfonyl)-4-(3-phenyl-4-((6-(trifl...)
Affinity DataEC50:  3.11E+3nMAssay Description:This assay is based on the ability of the LXR-LBDs (LXRα and LXRβ) to recruit and interact with a co-activator peptide. This assay was run ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetOxysterols receptor LXR-alpha(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM304593(methyl 2-(methylsulfonyl)-4-(3-phenyl-4-((6-(trifl...)
Affinity DataEC50:  1.94E+4nMAssay Description:This assay is based on the ability of the LXR-LBDs (LXRα and LXRβ) to recruit and interact with a co-activator peptide. This assay was run ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetOxysterols receptor LXR-alpha(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM304593(methyl 2-(methylsulfonyl)-4-(3-phenyl-4-((6-(trifl...)
Affinity DataIC50: 5.00E+4nMAssay Description:This assay is based on the ability of the LXR-LBDs (LXRα and LXRβ) to recruit and interact with a co-activator peptide. This assay was run ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

TargetOxysterols receptor LXR-beta(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM304593(methyl 2-(methylsulfonyl)-4-(3-phenyl-4-((6-(trifl...)
Affinity DataIC50: 5.00E+4nMAssay Description:This assay is based on the ability of the LXR-LBDs (LXRα and LXRβ) to recruit and interact with a co-activator peptide. This assay was run ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent