BDBM304962 2-{4,32-Dimethyl-30,30-dioxo-23-oxa-30λ6-thia-1,14,15,16-tetraazahexacyclo[20.8.1.13,7.19,13.012,16.024,29]tritriaconta-3,5,7(33),9,11,13(32),14,18,24(29),25,27-undecaen-8-yl}acetic acid::US10144731, Example 266

SMILES Cc1ccc2cc1CN1CC(CCC=CCn3nnc4c(C)c(ccc34)C2CC(O)=O)Oc2ccccc2S1(=O)=O

InChI Key InChIKey=UOLHWQPOVKEGJH-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 304962   

TargetKelch-like ECH-associated protein 1 [321-609](Human)
Glaxosmithkline

US Patent
LigandChemical structure of BindingDB Monomer ID 304962BDBM304962(US10144731, Example 266 | 2-{4,32-Dimethyl-30,30-d...)
Affinity DataIC50: 550nMAssay Description:100 nL of 100× compound dose response curves (serial 3-fold dilutions) in DMSO are stamped using an Echo liquid handling system (Labcyte) into 384-we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent

TargetNuclear factor erythroid 2-related factor 2(Human)
Glaxosmithkline

US Patent
LigandChemical structure of BindingDB Monomer ID 304962BDBM304962(US10144731, Example 266 | 2-{4,32-Dimethyl-30,30-d...)
Affinity DataEC50:  5.50E+3nMAssay Description:NAD(P)H:quinone oxidoreductase 1 (NQO1), also called DT diaphorase, is a homodimeric FAD-containing enzyme that catalyzes obligatory NAD(P)H-dependen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
US Patent