BDBM305282 1-(5-(3-cyano-6-(2- hydroxy-2- methylpropoxy)pyrazolo [1,5-a]pyridin-4-yl)pyridin- 2-yl)-4-methyl-N- ((tetrahydro-2H-pyran-3- yl)methyl)piperidine-4- carboxamide::US10144734, Example 298::US10172845, Example 298::US10441581, Example 298::US10881652, Example 298::US11648243, Example 298

SMILES CC(C)(O)COc1cc(-c2ccc(nc2)N2CCC(C)(CC2)C(=O)NCC2CCCOC2)c2c(cnn2c1)C#N

InChI Key InChIKey=NDTOMFSMXWWPFT-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 305282   

LigandPNGBDBM305282(US11648243, Example 298 | 1-(5-(3-cyano-6-(2- hydr...)
Affinity DataIC50: 94.9nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
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TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM305282(US11648243, Example 298 | 1-(5-(3-cyano-6-(2- hydr...)
Affinity DataIC50: 94.9nMAssay Description:Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent

LigandPNGBDBM305282(US11648243, Example 298 | 1-(5-(3-cyano-6-(2- hydr...)
Affinity DataIC50: 94.9nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

LigandPNGBDBM305282(US11648243, Example 298 | 1-(5-(3-cyano-6-(2- hydr...)
Affinity DataIC50: 94.9nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Array Biopharma

US Patent
LigandPNGBDBM305282(US11648243, Example 298 | 1-(5-(3-cyano-6-(2- hydr...)
Affinity DataIC50: 94.9nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent

LigandPNGBDBM305282(US11648243, Example 298 | 1-(5-(3-cyano-6-(2- hydr...)
Affinity DataIC50: 606nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent

LigandPNGBDBM305282(US11648243, Example 298 | 1-(5-(3-cyano-6-(2- hydr...)
Affinity DataIC50: 606nMAssay Description:Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2021
Entry Details
Go to US Patent

LigandPNGBDBM305282(US11648243, Example 298 | 1-(5-(3-cyano-6-(2- hydr...)
Affinity DataIC50: 606nMAssay Description:The potency of a compound inhibiting G810R mutant RET kinase was determined using CisBio's HTRF Kinease-TK assay technology. The assays contained...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent

LigandPNGBDBM305282(US11648243, Example 298 | 1-(5-(3-cyano-6-(2- hydr...)
Affinity DataIC50: 606nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

LigandPNGBDBM305282(US11648243, Example 298 | 1-(5-(3-cyano-6-(2- hydr...)
Affinity DataIC50: 606nMAssay Description:Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/30/2019
Entry Details
Go to US Patent