BDBM307973 BDBM307998::N-{5-chloro-4-[1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-6-yl]pyridin-2-yl}-3-azabicyclo[3.1.0]hexane-6-carboxamide::US9650358, Example 269

SMILES Clc1cnc(NC(=O)C2C3CNCC23)cc1-c1ccc2ncn(CC3CCOCC3)c2c1

InChI Key InChIKey=FKUCSDULCQKSCI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307973   

TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM307973(BDBM307998 | US9650358, Example 269 | N-{5-chloro-...)
Affinity DataIC50: 580nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent

TargetCyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM307973(BDBM307998 | US9650358, Example 269 | N-{5-chloro-...)
Affinity DataIC50: 290nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2019
Entry Details
US Patent