BDBM310250 Preparation (1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-((R)-pyrrolidin-3-yl)-4H-1,2,4-triazol-3-yl)-1-methoxy-1-(5-methylpyrimidin-2-yl)propane-2-sulfonamide and (1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-((S)-pyrrolidin-3-yl)-4H-1,2,4-triazol-3-yl)-1-methoxy-1-(5-methylpyrimidin-2-yl)propane-2-sulfonamide::US10150760, Example 45.0

SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](OC)c2ncc(C)cn2)nnc1[C@@H]1CCNC1

InChI Key InChIKey=MZGAEVHCAXPKBA-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 310250   

TargetApelin receptor(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 310250BDBM310250(US10150760, Example 45.0 | Preparation (1R,2S)-N-(...)
Affinity DataEC50:  510nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
US Patent