BDBM31088 1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine::1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine::CHIR-265::[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridyl]oxy]benzimidazol-2-yl]-[4-(trifluoromethyl)phenyl]amine::cid_11656518
SMILES Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12
InChI Key InChIKey=YABJJWZLRMPFSI-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 833 hits for monomerid = 31088
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of B-RAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 13nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 13nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 13nMAssay Description:Binding constant for DDR1 kinase domainMore data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of wild type c-RAF (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human GST-tagged BRAF V600E mutant expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of c-KIT (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1/2/3(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of VEGFR (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of B-RAF V600E mutant in human A375 cells assessed as phosphorylation of ERKMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of B-RAF V600E mutant in human Malme-3M cells assessed as phosphorylation of ERKMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of B-RAF V600E mutant in human WM-1799 cells assessed as phosphorylation of ERKMore data for this Ligand-Target Pair
Affinity DataKd: 43nMAssay Description:Binding constant for EPHB6 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 54nMAssay Description:Binding constant for YSK4 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 55nMAssay Description:Binding constant for GCN2(Kin.Dom.2,S808G) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 55nMAssay Description:Binding constant for GCN2(Kin.Dom.2,S808G) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 60nMAssay Description:Binding constant for LOK kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 60nMAssay Description:Binding constant for LOK kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 63nMAssay Description:Binding constant for ZAK kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 63nMAssay Description:Binding constant for ZAK kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 63nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of wild type B-RAF (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 72nMAssay Description:Binding constant for RET(M918T) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 72nMAssay Description:Binding constant for RET(M918T) kinase domainMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T](Human)
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataKd: 72nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKd: 83nMAssay Description:Binding constant for KIT(L576P) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 87nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 87nMAssay Description:Binding constant for CIT kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 87nMAssay Description:Binding constant for CIT kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 89nMAssay Description:Binding constant for RET(V804M) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 140nMAssay Description:Binding constant for TAOK2 kinase domainMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of B-RAF V600E mutant in human SK-MEL-28 cells assessed as phosphorylation of ERKMore data for this Ligand-Target Pair
Affinity DataKd: 150nMAssay Description:Binding constant for RET kinase domainMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T](Human)
Ambit Biosciences
Curated by PubChem BioAssay
Ambit Biosciences
Curated by PubChem BioAssay
Affinity DataKd: 150nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 150nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 150nMAssay Description:Binding constant for TIE1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 150nMAssay Description:Binding constant for RET kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 150nMAssay Description:Binding constant for TIE1 kinase domainMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKd: 170nMAssay Description:Binding constant for KIT(V559D) kinase domainMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKd: 170nMAssay Description:Binding constant for KIT(V559D) kinase domainMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKd: 200nMAssay Description:Binding constant for KIT kinase domainMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKd: 200nMAssay Description:Binding affinity to human KIT incubated for 1 hr by kinase binding assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKd: 200nMAssay Description:Binding constant for KIT kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 210nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 210nMAssay Description:Binding constant for ABL1(M351T) kinase domainMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKd: 240nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKd: 240nMAssay Description:Binding constant for PDGFRB kinase domainMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKd: 240nMAssay Description:Binding constant for PDGFRB kinase domainMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKd: 240nMAssay Description:Binding constant for KIT(V559D,T670I) kinase domainMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataKd: 240nMAssay Description:Binding constant for KIT(V559D,T670I) kinase domainMore data for this Ligand-Target Pair
