BDBM311539 Ex. Cpd. 4::US10807986, Example 4::US11046696, Compound 4

SMILES Nc1ncnc2n(nc(C(=O)Nc3ccc(cc3)-c3ccco3)c12)C1CCCC1

InChI Key InChIKey=HKAQBWIYYNUDNW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 311539   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 311539BDBM311539(Ex. Cpd. 4 | US10807986, Example 4 | US11046696, C...)
Affinity DataIC50: 6.30nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 311539BDBM311539(Ex. Cpd. 4 | US10807986, Example 4 | US11046696, C...)
Affinity DataIC50: 6.30nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 311539BDBM311539(Ex. Cpd. 4 | US10807986, Example 4 | US11046696, C...)
Affinity DataIC50: 6.30nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 311539BDBM311539(Ex. Cpd. 4 | US10807986, Example 4 | US11046696, C...)
Affinity DataIC50: 6.80nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET (V804L or V804M) (i.e., RET with V804L or V804M mut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 311539BDBM311539(Ex. Cpd. 4 | US10807986, Example 4 | US11046696, C...)
Affinity DataIC50: 6.80nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804L](Human)
Taiho Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 311539BDBM311539(Ex. Cpd. 4 | US10807986, Example 4 | US11046696, C...)
Affinity DataIC50: 6.80nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET (V804L) (i.e., RET with V804L mutation) kinase acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
US Patent