BDBM313518 2-(2-cyanopropan-2-yl)- N-(3'-(3-fluorooxetan-3- yl)-5'-(3-hydroxyoxetan- 3-yl)-6-methyl-[1,1'- biphenyl]-3- yl)isonicotinamide::US10167279, Example 138

SMILES Cc1ccc(NC(=O)c2ccnc(c2)C(C)(C)C#N)cc1-c1cc(cc(c1)C1(F)COC1)C1(O)COC1

InChI Key InChIKey=XUTPNQCCUPMLOT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 313518   

TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM313518(2-(2-cyanopropan-2-yl)- N-(3'-(3-fluorooxetan-3- y...)
Affinity DataIC50:  2.19E+3nMAssay Description:Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent