BDBM315088 ((1S,4R,6R)-6-((5-bromopyridin-2-yl)oxy)-2-azabicyclo[2.2.2]octan-2-yl)(3-fluoro-2-(pyrimidin-2-yl)phenyl)methanone::US10183953, Example 269::US9611277, Example 269

SMILES Fc1cccc(C(=O)N2CC3CCC2C(C3)Oc2ccc(Br)cn2)c1-c1ncccn1

InChI Key

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 315088   

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM315088(US10183953, Example 269 | ((1S,4R,6R)-6-((5-bromop...)
Affinity DataKi:  4nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Rat)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM315088(US10183953, Example 269 | ((1S,4R,6R)-6-((5-bromop...)
Affinity DataKi:  4nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM315088(US10183953, Example 269 | ((1S,4R,6R)-6-((5-bromop...)
Affinity DataKi:  5nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM315088(US10183953, Example 269 | ((1S,4R,6R)-6-((5-bromop...)
Affinity DataKi:  5nMAssay Description:CHO cells stably transfected with the human orexin 1 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM/F12, 10% FBS, 1×...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM315088(US10183953, Example 269 | ((1S,4R,6R)-6-((5-bromop...)
Affinity DataKi:  363nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat # SH30022), 10%...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM315088(US10183953, Example 269 | ((1S,4R,6R)-6-((5-bromop...)
Affinity DataKi:  363nMAssay Description:PFSK-1 cells endogenously expressing the human orexin 2 receptor were grown to confluency in RPMI1640 (Hyclone, cat #30027.02), 10% FBS, 1× pen-strep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent