BDBM315318 3-{1-[3-Methyl-1-(4-trifluoromethyl-phenyl)-1H-pyrazol-4-ylmethyl]-piperidin-4-yl}-3,4-dihydro-1H-quinazolin-2-one::US10172843, Example 52

SMILES Cc1nn(cc1CN1CCC(CC1)N1Cc2ccccc2NC1=O)-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=NJTJBNWKCDTLRU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 315318   

TargetCathepsin S(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM315318(US10172843, Example 52 | 3-{1-[3-Methyl-1-(4-trifl...)
Affinity DataIC50: 1.38E+3nMAssay Description:Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
US Patent