BDBM316541 4-(4-{[(3R)-1-acryloylpiperidin-3-yl]amino}-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-N-(propan-2-yl)benzamide::US11111242, Example 29::US9617258, Example 29

SMILES C=CC(=O)N1CCC[C@@H](Nc2ncnc3[nH]cc(-c4ccc(C(=O)NC(C)C)cc4)c23)C1

InChI Key InChIKey=VKJYPHPSYFRQJB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 316541   

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 316541BDBM316541(4-(4-{[(3R)-1-acryloylpiperidin-3-yl]amino}-7H-pyr...)
Affinity DataIC50: 6.60nMAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 316541BDBM316541(4-(4-{[(3R)-1-acryloylpiperidin-3-yl]amino}-7H-pyr...)
Affinity DataIC50: 6.60nMAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 316541BDBM316541(4-(4-{[(3R)-1-acryloylpiperidin-3-yl]amino}-7H-pyr...)
Affinity DataIC50: 6.60nMAssay Description:JAK Caliper Enzyme Assay at 4 μM: Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 316541BDBM316541(4-(4-{[(3R)-1-acryloylpiperidin-3-yl]amino}-7H-pyr...)
Affinity DataIC50: 665nMAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 316541BDBM316541(4-(4-{[(3R)-1-acryloylpiperidin-3-yl]amino}-7H-pyr...)
Affinity DataIC50: 665nMAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2025
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 316541BDBM316541(4-(4-{[(3R)-1-acryloylpiperidin-3-yl]amino}-7H-pyr...)
Affinity DataIC50: 665nMAssay Description:JAK Caliper Enzyme Assay at 1 mM ATP: Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent