BDBM317787 US11337976, Compound P-0289::US20230277534, Compound P-0289::US9624213, Compound P-0289

SMILES F[C@H]1CCN(C1)S(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2cnc(nc2)C2CC2)c1F

InChI Key InChIKey=YYACLQUDUDXAPA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 317787   

TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM317787(US9624213, Compound P-0289 | US11337976, Compound ...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM317787(US9624213, Compound P-0289 | US11337976, Compound ...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of N-terminal His-tagged BRAF V600E mutant (unknown origin) expressed in baculovirus infected insect cells co-expressing CDC37 using bioti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Plexxikon

US Patent
LigandPNGBDBM317787(US9624213, Compound P-0289 | US11337976, Compound ...)
Affinity DataIC50: 100nMAssay Description:The biochemical activity IC50 values are determined with respect to inhibition of B-Raf V600E kinase activity or p-Erk kinase activity, where inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Plexxikon

US Patent
LigandPNGBDBM317787(US9624213, Compound P-0289 | US11337976, Compound ...)
Affinity DataIC50: 100nMAssay Description:For example, the biochemical activity IC50 values are determined with respect to inhibition of B-Raf V600E kinase activity or p-Erk kinase activity, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Plexxikon

US Patent
LigandPNGBDBM317787(US9624213, Compound P-0289 | US11337976, Compound ...)
Affinity DataIC50: 100nMAssay Description:Assays for biochemical and cell based activity are known in the art, for example, as described in PCT publication WO 2007/002433, the disclosure of w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent