BDBM318023 8-Methyl-2-[4-[(5- methylpyrimidin-2- yl)methyl]piperazin-1-yl]- 3,5,6,7-tetrahydropyrido[2,3- d]pyrimidin-4-one::US9624218, Example 17

SMILES Cc1cnc(CN2CCN(c3nc4c(c(=O)[nH]3)CCCN4C)CC2)nc1

InChI Key InChIKey=RFQQBDRYILMLKX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 318023   

TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
Eli Lilly

US Patent
LigandChemical structure of BindingDB Monomer ID 318023BDBM318023(8-Methyl-2-[4-[(5- methylpyrimidin-2- yl)methyl]pi...)
Affinity DataIC50: 67.6nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
Eli Lilly

US Patent
LigandChemical structure of BindingDB Monomer ID 318023BDBM318023(8-Methyl-2-[4-[(5- methylpyrimidin-2- yl)methyl]pi...)
Affinity DataIC50: 81.5nMAssay Description:The enzymatic activity of hTNKS1 and hTNKS2 is assessed using an enzyme-linked immunosorbent assay (ELISA) which detects poly ADP ribose incorporated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Eli Lilly

US Patent
LigandChemical structure of BindingDB Monomer ID 318023BDBM318023(8-Methyl-2-[4-[(5- methylpyrimidin-2- yl)methyl]pi...)
Affinity DataIC50: 7.22E+3nMAssay Description:The Poly ADP-ribose polymerase 1(PARP1) assay is an ELISA which detects poly ADP ribose incorporated into plate-bound histone protein in a 384-well f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent