BDBM318851 (R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-(2-methoxypyridin-3-yl)-1-methyl-5,6-dihydropyrrolo[3,4-c]pyrazol-4(1H)-one::US9624247, Example 13

SMILES COc1ncccc1-c1nn(C)c2[C@H](N(C(=O)c12)c1cc(C)c2nnc(C)n2c1)c1ccc(Cl)cc1

InChI Key InChIKey=XZYFNQNYLMTZIS-JOCHJYFZSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 318851   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM318851((R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tria...)
Affinity DataIC50:  24nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCREB-binding protein(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM318851((R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tria...)
Affinity DataIC50:  5.40E+3nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM318851((R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tria...)
Affinity DataIC50:  22nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM318851((R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tria...)
Affinity DataIC50:  34nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent