BDBM320449 2-(3,4-dichloro-5-fluorobenzyl)- 1H-pyrrolo[3,2-b]pyridine-7- carboxylic acid::US10174026, Example 132::US9738637, Example 132

SMILES OC(=O)c1ccnc2cc(Cc3cc(F)c(Cl)c(Cl)c3)[nH]c12

InChI Key InChIKey=GMVQFVAPKMAASG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 320449   

TargetLysine-specific demethylase 4A(Human)
Celgene Quantical Research

US Patent
LigandPNGBDBM320449(US10174026, Example 132 | 2-(3,4-dichloro-5-fluoro...)
Affinity DataIC50: 550nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2A was determined in 384-well plate format under the following reaction conditions: 2 nM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
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TargetLysine-specific demethylase 4C(Human)
Celgene Quantical Research

US Patent
LigandPNGBDBM320449(US10174026, Example 132 | 2-(3,4-dichloro-5-fluoro...)
Affinity DataIC50: 550nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent

TargetLysine-specific demethylase 5B(Human)
Celgene Quantical Research

US Patent
LigandPNGBDBM320449(US10174026, Example 132 | 2-(3,4-dichloro-5-fluoro...)
Affinity DataIC50: 5.50E+3nMAssay Description:The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent

TargetLysine-specific demethylase 5A(Human)
Celgene Quantical Research

US Patent
LigandPNGBDBM320449(US10174026, Example 132 | 2-(3,4-dichloro-5-fluoro...)
Affinity DataIC50: 5.50E+3nMAssay Description:The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent