BDBM320793 (R)- or (S)-6-(Dimethylamino)-1-(1-(2- fluoro-4-(trifluoromethyl)phenyl)propyl)-3- (fluoromethyl)-1H-pyrazolo[3,4- d]pyrimidin-4(5H)-one::US10174037, Example 198::US10174037, Example 199

SMILES CCC(c1ccc(cc1F)C(F)(F)F)n1nc(CF)c2c1nc([nH]c2=O)N(C)C

InChI Key InChIKey=JPLWZCAWEPJJGL-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 320793   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320793((R)- or (S)-6-(Dimethylamino)-1-(1-(2- fluoro-4-(t...)
Affinity DataKi:  0.0480nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320793((R)- or (S)-6-(Dimethylamino)-1-(1-(2- fluoro-4-(t...)
Affinity DataKi:  0.0680nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320793((R)- or (S)-6-(Dimethylamino)-1-(1-(2- fluoro-4-(t...)
Affinity DataKi:  1.10nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent