BDBM320864 3-Methyl-6-(methylamino)-1- (1-(4- (trifluoromethyl)phenyl)ethyl)- 1,5-dihydro-4H-pyrazolo[3,4- d]pyrimidin-4-one::US10174037, Example 269

SMILES CNc1nc2n(nc(C)c2c(=O)[nH]1)C(C)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=PBAYIKNKJDSPLR-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 320864   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320864(US10174037, Example 269 | 3-Methyl-6-(methylamino)...)
Affinity DataKi:  85nMAssay Description:Performed by Lab A. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320864(US10174037, Example 269 | 3-Methyl-6-(methylamino)...)
Affinity DataKi:  139nMAssay Description:Performed by Lab A. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent