BDBM320870 (R)- or (S)-1-(1-(4- Cyclopropylphenyl)ethyl)-3- (difluoromethyl)-6-hydroxy- 1H-pyrazolo[3,4-d]pyrimidin- 4(5H)-one::US10174037, Example 275::US10174037, Example 276

SMILES CC(c1ccc(cc1)C1CC1)n1nc(C(F)F)c2c1nc(O)[nH]c2=O

InChI Key InChIKey=VQDMRIKYXFHQIL-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 320870   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320870((R)- or (S)-1-(1-(4- Cyclopropylphenyl)ethyl)-3- (...)
Affinity DataKi:  3.60nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320870((R)- or (S)-1-(1-(4- Cyclopropylphenyl)ethyl)-3- (...)
Affinity DataKi:  416nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent