BDBM320892 (S)-2-(6-Hydroxy-4-oxo-1-(1-(4- (trifluoromethyl)phenyl)ethyl)-4,5- dihydro-1H-pyrazolo[3,4- d]pyrimidin-3-yl)acetonitrile::US10174037, Example 298

SMILES C[C@@H](c1ccc(cc1)C(F)(F)F)n1nc(CC#N)c2c1nc(O)[nH]c2=O

InChI Key InChIKey=AMTFEJMXOOOSAM-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 320892   

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320892(US10174037, Example 298 | (S)-2-(6-Hydroxy-4-oxo-1...)
Affinity DataKi:  4.70nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetPhosphodiesterase(Rhesus macaque)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320892(US10174037, Example 298 | (S)-2-(6-Hydroxy-4-oxo-1...)
Affinity DataKi:  5nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent